GHK-Cu Copper Peptide

The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive.

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Skin & Hair

GHK was first studied for wound healing (1983+) and later for its effects on skin and hair. In many controlled, peer-reviewed published articles, GHK was found to:

  • Tightened and Loose Skin
    and thicken older skin.
  • Repaired
    protective skin barrier proteins.
  • Improved
    skin firmness, elasticity, and clarity.
  • Reduced fine lines
    depth of wrinkles, and overall appearance.
  • Reduced fine lines
    depth of wrinkles, and overall appearance.
  • Smoothed
    rough skin.
  • Reduced Photodamage
    mottled hyperpigmentation, skin spots and lesions.
  • Improved
    overall appearance.
  • Protected skin cells
    from UV radiation.
  • Increased Hair Growth
    and thickness, enlarge hair follicle size.
  • Accelerated Wound Healing
    but better when used in liposomes due to its sensitivity to carboxypeptidase breakdown effects.

Anti-Cancer Actions

  • Topped 1,309 bioactive compounds
    as the Broad Institute computer recommended molecule for the treatment of human METASTATIC COLON CANCER
  • GHK, at 1 nanomolar
    reset the PROGRAMMED CELL DEATH system in human cancer cells (human neuroblastoma, leukemia, and breast cancer) but did not affect healthy cells.
  • GHK-copper plus
    ascorbic acid suppressed a sarcoma in mice.
  • GHK inhibited NFKB p65
    which is believed to promote cancer growth.
  • Repaired Damaged DNA
    at cellular level at 1 nanomolar (47 genes up, 5 genes down).
  • GHK-copper
    induced cell differentiation.
  • Reset 84 genes
    to growth inhibition or cancer inhibition.

Lung Protection

  • Topped 1,309 bioactive compounds
    as Broad Institute computer recommended molecule for treatment of chronic obstructive obstructive pulmonary disease. Restored healthy function in COPD affected cells at 10 nanomolar.
  • Protected Lung Cells
    from damage by both bleomycin and lipopolysaccharide-induced injury.
  • In fetal lung cells
    GHK-Cu (at concentrations of 0.1, 1.0, and 10 nanomolar) produced dose-response changes in 329 human fetal lung genes of the extracellular matrix.

Antioxidant / Anti-Inflammatory

  • Increased SOD1 Activity
    Suppressed toxic products of lipid oxidation alpha,beta-4-hydroxy-trans-2-noneal and acrolein, peroxyl radicals, hydroxyl radicals, p38 MAPK, IL-6, IL-17, TNF alpha, and strongly suppressed NFKB, a molecule which is believed to be a primary cause of many diseases of aging.
  • Completely Blocked CU2+ Oxidation
    of low density lipoproteins while SOD1 gave only 20% blocking.
  • Blocked Release of
    Oxidizing iron from ferritin.

Brain & Nerves

  • Altered expression of human genes
    important in neuron function by 50%, plus or minus, with 408 UP and 230 DOWN.
  • Induced strong Anti-Anxiety & Anti-Aggression
    effects in rats within 12 minutes at a weight equivalent of 35 micrograms in 70 Kg humans.
  • Induced Anti-Pain Activity
    in rats within 12 minutes.
  • Alleviated neuronal apoptosis
    due to Intracerebral hemorrhage.
  • Now used clinically in humans
    for the treatment of damaged spinal segments in the neck. Treatment was for 20 days with a daily injection of 0.25 mg GHK-Cu into the skin around the damaged area. The cost of GHK-Cu is about $0.01 a milligram.

Stem Cells & OTher Actions

  • Caused adult MCS Stem Cells
    to produce more growth factors, increased stem cell differentiation.
  • Enhanced activity of
    alginate hydrogels for human cord blood MCS Stem Cell Ostegenesis.


  • Increased the healing of
    many tissues including skin, stomach, intestine lining, bone tissue.
  • Strongly chemo-attracted
    capillary cells, mast cells, and macrophages.
  • Strongly activated genes of
    the Ubiquitin proteasome system used for cell cleansing. (41 genes up, 1 gene down).
  • Blocked Locked Cortisone's
    anti-regeneration effects.
  • Suppressed the Insulin
    and insulin-like system that reduces lifespan in roundworms.
  • Reduced Fibrinogen synthesis
    Fibrinogen levels are the top predictor of cardiovascular heart disease.
  • Increased Myostatin
    gene expression 9.4 fold. Myostatin inhibits heart failure.